The Effects of Mitiglinide and Repaglinide on Postprandial Hyperglycemia in Patients Undergoing Methylprednisolone Pulse Therapy
نویسندگان
چکیده
One adverse effect of methylprednisolone (MP) pulse therapy is an acute dose-dependent increase in the blood glucose level. Five patients with thyroid ophthalmopathy but normal glucose tolerance received MP pulse therapy (3 cycles, 3 days/week) and were assessed by continuous glucose monitoring. Steroid therapy increased the mean sensor glucose level, and all patients developed steroid-induced diabetes. The patients were treated alternately with mitiglinide (30 mg/day) and repaglinide (1.5 mg/day) during the second or third MP pulse therapy. The sensor glucose levels before lunch and dinner were more favorable during treatment with repaglinide than during treatment with mitiglinide. Repaglinide may be more clinically appropriate than mitiglinide.
منابع مشابه
Calcium and phosphorus metabolism during methylprednisolone puls therapy
intravenous glucocorucoid pulse therapy is a common treatment for immunologically origin diseases but it can not be considered a completely bening treatment.the effects of long term administration of glucocorticoids on calcium and phosphorus metabolism are week known ,but is less in known about the effect of pluse therapy.the purpose of this study was to investigate the effect of methylpredn...
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